The synopsis for this grant opportunity is detailed below, following
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document that have been posted as of
07/07/2009
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Document Type:
Grants Notice
Funding Opportunity Number:
RFA-DE-10-001
Opportunity Category:
Discretionary
Posted Date:
Jul 07, 2009
Creation Date:
Jul 07, 2009
Original Closing Date for Applications:
Dec 02, 2009
Current Closing Date for Applications:
Dec 02, 2009
Archive Date:
Jan 02, 2010
Funding Instrument Type:
Grant
Category of Funding Activity:
Health
Category Explanation:
Expected Number of Awards:
Estimated Total Program Funding:
$2,000,000
Award Ceiling:
Award Floor:
CFDA Number(s):
93.121
--
Oral Diseases and Disorders Research
Cost Sharing or Matching Requirement:
No
Eligible Applicants
State governments
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For profit organizations other than small businesses
Small businesses
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Additional Information on Eligibility:
Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Agency Name
National Institutes of Health
Description
Purpose. This FOA issued by the NIDCR, NIH, solicits R01 applications that focus on harnessing oral mucosal and innate immunity to develop prophylactic HIV vaccines delivered through the oral mucosa. Specifically, the NIDCR is seeking applications that will address studies on the: 1) mechanisms linking oral mucosal and innate immunity with systemic adaptive immunity; 2) development of HIV vaccine antigens in oral expression vectors that are stable in the oral cavity and have the ability to trigger anti-HIV protective immunity; 3) mechanisms of HIV infection of target cells in the oral cavity (e.g., epithelial cells and immune cells) and effects of oral dendritic (DC),and natural killer (NK) cell subset changes during disease progression or upon oral mucosal HIV vaccination; 4) DC-NK cells cross-talk in the oral cavity and relationship to systemic adaptive immunity upon oral mucosal HIV vaccination; 5) similarities and differences between DC-NK cells cross-talk in the oral mucosal site compared with other mucosal sites, and 6) characterization of soluble defense molecules produced in oral secretions upon oral mucosal HIV vaccination. This FOA welcomes applications that further develop already characterized target vaccine antigens and formulations and relevant model antigens for oral delivery, target validation and early preclinical evaluation in relevant animal models. This FOA will not support basic vaccine antigen discovery, HIV vaccine clinical trials, projects on enteric vaccines for oral delivery, projects on nasal delivery methods for oral mucosal HIV vaccines, or therapeutic vaccine research.
Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism.
Funds Available and Anticipated Number of Awards. NIDCR intends to commit approximately $2 million in total costs (Direct costs plus Facilities and Administrative costs) in fiscal year 2010 through this announcement to support approximately 4-6 awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.
